Nucks1 - nuclear casein kinase and cyclin-dependent kinase substrate 1

Predicted to enable DNA binding activity; chromatin binding activity; and transcription coactivator activity. Involved in several processes, including cellular glucose homeostasis; positive regulation of transcription by RNA polymerase II; and regulation of insulin receptor signaling pathway. Acts upstream of or within glucose homeostasis and positive regulation of insulin receptor signaling pathway. Located in chromatin; cytoplasm; and nucleus. Is expressed in central nervous system; embryo; liver; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human NUCKS1 (nuclear casein kinase and cyclin dependent kinase substrate 1). [provided by Alliance of Genome Resources, Apr 2022]