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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
CDK1 - Cyclin Dependent Kinase 1
Alias:
CDC2
CDC28A
P34CDC2
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是Ser/Thr蛋白激酶家族的成员。这个蛋白质是高度保守的蛋白激酶复合物M期促进因子(MPF)的催化亚单位,对于真核细胞周期的G1/S和G2/M期过渡是必不可少的。有丝分裂细胞周期蛋白稳定地与这个蛋白质结合并作为调节亚单位发挥作用。这个蛋白质的激酶活性受到细胞周期中细胞周期蛋白积累和破坏的控制。这个蛋白质的磷酸化和脱磷酸化也在细胞周期控制中起着重要的调节作用。已经发现这个基因的不同剪接转录变异体编码不同的异构体。[RefSeq,2009年3月提供]
Related ID:
NCBI:983
ENSEMBL:ENSG00000170312
HGNC:1722
UNIPROT:P06493
OMIM:116940
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
983
6
8
16522 bp
34.09
3
--
14
61
CDK1 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
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Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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