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中文人类
ESPL1 - Extra Spindle Pole Bodies Like 1, Separase
Alias:
ESP1
SEPA
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姐妹染色单体在减数分裂前紧密连接并在减数分裂过程中及时分离对于染色体继承至关重要。在脊椎动物中，姐妹染色单体连接通过两个不同的机制分两个步骤释放。第一步涉及在cohesin复合体中磷酸化STAG1（MIM 604358）或STAG2（MIM 300826）。第二步涉及由ESPL1或分离酶切割cohesin亚单位SCC1（RAD21；MIM 606462），这开始了姐妹染色单体的最终分离（Sun等人，2009年[PubMed 19345191]）。[由OMIM于2010年11月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
ESPL1 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
