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中文人类
RAPGEF2 - Rap Guanine Nucleotide Exchange Factor 2
Alias:
RAGEF
RA-GEF
NRAPGEP
PDZGEF1
Rap-GEP
CNrasGEF
PDZ-GEF1
RA-GEF-1
nRap GEP
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RAS家族的GTP酶成员作为GTP/GDP调控开关，在信号传导中起着作用，它们在无活性的GDP结合状态和有活性的GTP结合状态之间循环。鸟苷酸交换因子（GEFs），如RAPGEF2，作为RAS的激活剂，通过促进GTP的获取来维持活性GTP结合状态，它们是细胞表面受体与RAS激活之间的关键链接（Rebhun等，2000年[PubMed 10934204]）。[由OMIM于2008年3月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
RAPGEF2 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
