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中文人类
MDC1 - Mediator Of DNA Damage Checkpoint 1
Alias:
NFBD1
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这个基因编码的蛋白质含有N端翼状域，两个BRCA1 C端（BRCT）基序和中央结构域，具有13个重复的约41个氨基酸序列。该编码蛋白质是激活S期内和G2/M期细胞周期检查点所必需的，以响应DNA损伤。这种核蛋白通过其BRCT基序与DNA双链断裂附近的磷酸化组蛋白H2AX相互作用，并促进ATM激酶和减数分裂重组11蛋白复合物招募到DNA损伤焦点。[由RefSeq，2008年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
MDC1 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
