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中文人类
PPM1F - Protein Phosphatase, Mg2+/Mn2+ Dependent 1F
Alias:
CAMKP
FEM-2
POPX2
hFEM-2
CaMKPase
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这个基因编码的蛋白质是Ser/Thr蛋白磷酸酶PP2C家族的成员。PP2C家族成员已知是细胞应激响应途径的负调控因子。这个磷酸酶可以与Rho鸟苷酸交换因子(PIX)相互作用，从而阻止p21激活的激酶1(PAK)的生物学效应，PAK是一种在Rho GTPases下游调节生物学效应的蛋白激酶。已发现钙/钙调素依赖性蛋白激酶IIγ(CAMK2G/CAMK-II)是这个磷酸酶的一个底物。过表达这个磷酸酶或CAMK2G已经显示可以调节半胱天冬酶依赖的凋亡。已经发现了一种替代剪接的转录变异体，但其全长性质尚未确定。[由RefSeq，2008年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
PPM1F Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
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Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
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Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
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Residues
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Score
Related Mouse Models
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Name
MGI
Strain of Origin
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CAS Number
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Link
References Literature
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