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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
TRAF4 - TNF Receptor Associated Factor 4
Alias:
CART1
MLN62
RNF83
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码TNF受体相关因子(TRAF)家族的一员。TRAF蛋白与TNF受体超家族的成员结合并调节其信号传导。编码的蛋白质已被证明与神经生长因子受体p75(NTR/NTSR1)相互作用,并负调控NTR诱导的细胞死亡和NF-kappa B激活。该蛋白质已被发现与p47phox结合,p47phox是一个包含在称为NAD(P)H氧化酶的多蛋白复合体中的胞质调节因子。因此,该蛋白质被认为涉及MAPK8/JNK的氧化活化。观察到了可变剪接的转录本,但只有一个人的完整长度已被确定。[由RefSeq,2008年7月提供]
Related ID:
NCBI:9618
ENSEMBL:ENSG00000076604
HGNC:12034
UNIPROT:Q9BUZ4
OMIM:602464
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
9618
6
7
6946 bp
53.54
14
--
7
24
TRAF4 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
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Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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Status
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