Log In|Sign Up
中文人类
CLOCK - Clock Circadian Regulator
Alias:
KAT13D
bHLHe8
Favorite
这个基因编码的蛋白质在调节昼夜节律中起核心作用。该蛋白质编码一个基本的螺旋-环-螺旋(bHLH)家族的转录因子，并具有DNA结合组蛋白乙酰转移酶活性。编码的蛋白质与ARNTL(BMAL1)形成异源二聚体，结合周期(PER1, PER2, PER3)和隐花色素(CRY1, CRY2)基因上游的E-盒增强子元素，并激活这些基因的转录。PER和CRY蛋白异源二聚化，并通过与CLOCK/ARNTL复合物在反馈环路中相互作用，抑制它们自己的转录。这个基因的多态性可能与某些人群的行为变化以及肥胖和代谢综合症相关。可选的剪接导致多个转录变异体。[由RefSeq，2014年1月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
CLOCK Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
