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中文人类
TP53I3 - Tumor Protein P53 Inducible Protein 3
Alias:
PIG3
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这个基因编码的蛋白质与氧化还原酶相似，这些酶涉及细胞对氧化应激和辐射的响应。这个基因受到肿瘤抑制因子p53的诱导，被认为涉及p53介导的细胞死亡。它的启动子区域含有一个p53共识结合位点，并具有一个下游的五核苷酸微卫星序列。已经表明，p53通过与下游五核苷酸微卫星序列相互作用，可转录激活此基因。该微卫星是多样的，五核苷酸重复数量的变化直接与p53诱导的转录激活程度相关。有人提出，微卫星多态性可能与癌症易感性的差异有关。已发现此基因的不同剪接转录变异体，编码不同的异构体。[RefSeq提供，2011年5月]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
TP53I3 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
