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中文人类
LITAF - Lipopolysaccharide Induced TNF Factor
Alias:
PIG7
SIMPLE
TP53I7
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脂质多糖是一种强大的单核细胞和巨噬细胞刺激剂，导致肿瘤坏死因子-α（TNF-α）和其他炎症介质的分泌。这个基因编码脂质多糖诱导的TNF-α因子，这是一个DNA结合蛋白，可以通过直接结合TNF-α基因的启动子区域来调节TNF-α的表达。这个基因的转录受到肿瘤抑制因子p53的诱导，并与p53诱导的凋亡途径有关。这个基因的突变导致Charcot-Marie-Tooth疾病1C型（CMT1C），并可能涉及乳腺外Paget病的癌发生。已经在这个基因中发现了多种替代剪接的转录变异体。[由RefSeq，2014年12月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
LITAF Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
