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中文人类
MAPK8IP1 - Mitogen-activated Protein Kinase 8 Interacting Protein 1
Alias:
IB1
JIP1
JIP-1
PRKM8IP
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这个基因编码一个胰腺β细胞功能的调节因子。它与JIP-1高度相似，JIP-1是一种已知能调节c-Jun氨基端激酶（Mapk8）的小鼠蛋白质。这种蛋白质已被证明能防止MAPK8介导的转录因子的激活，并减少胰腺β细胞中IL-1β和MAP激酶激酶1（MEKK1）诱导的凋亡。这种蛋白质还作为葡萄糖转运蛋白GLUT2的DNA结合转激活子发挥作用。据报道，RE1沉默转录因子（REST）能抑制胰岛素分泌的β细胞中这个基因的表达。这个基因在2型糖尿病家庭中发现存在突变，因此被认为是一个2型糖尿病的易感基因。[RefSeq，2011年5月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
MAPK8IP1 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
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Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
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Tile View
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Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
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Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
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CAS Number
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References Literature
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