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中文人类
MAP4K4 - Mitogen-activated Protein Kinase Kinase Kinase Kinase 4
Alias:
HGK
NIK
MEKKK4
FLH21957
HEL-S-31
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这个基因编码的蛋白质是丝氨酸/苏氨酸蛋白激酶家族的成员。这个激酶已被证明能特异性地激活MAPK8/JNK。通过这个激酶激活MAPK8被发现受到MAP3K7/TAK1、MAP2K4/MKK4和MAP2K7/MKK7的显性负突变体的抑制，这表明这个激酶可能通过MAP3K7-MAP2K4-MAP2K7激酶级联来发挥作用，并调节TNF-α信号通路。已经发现了编码不同异构体的可变剪接转录变异体。[由RefSeq，2008年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
MAP4K4 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
