Contributes to ATP hydrolysis activity. Involved in several processes, including negative regulation of icosanoid secretion; positive regulation of heart rate; and response to muscle activity. Located in cell surface; extracellular space; and mitochondrion. Part of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o). Used to study pulmonary hypertension. Biomarker of pulmonary hypertension. Orthologous to human ATP5PF (ATP synthase peripheral stalk subunit F6). [provided by Alliance of Genome Resources, Apr 2022]