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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Selenof - selenoprotein F
Alias:
Sep15
9430015P09Rik
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码的蛋白质属于SEP15/硒蛋白M家族。虽然这个蛋白质的精确功能尚不清楚,但它已经发现与UDP-葡萄糖:糖蛋白葡萄糖基转移酶(UGTR),一种内质网(ER)驻留蛋白,有关,该蛋白参与蛋白质折叠的质量控制。与UGTR的结合将这个蛋白质保留在内质网中,在那里它可能参与蛋白质折叠。在鼠的敲除研究中,这个基因也参与白内障的形成和结肠癌的发生。这个蛋白质是一个硒蛋白,含有罕见的氨基酸硒代半胱氨酸(Sec)。Sec由UGA密码子编码,该密码子通常表示翻译终止。硒蛋白mRNA的3'UTR含有保守的茎环结构,称为Sec插入序列(SECIS)元素,该元素对于将UGA识别为Sec密码子而不是作为停止信号是必要的。[由RefSeq,2016年11月提供]
Related ID:
NCBI:93684
ENSEMBL:ENSMUSG00000037072
UNIPROT:Q9ERR7
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
93684
1
5
27251 bp
17.81
5
5
Selenof Genetics information (+)
GRCm39
Sequence Homology
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* This data comes from NCBI.
Gene Expression
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