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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
SOCS6 - Suppressor Of Cytokine Signaling 6
Alias:
CIS4
SSI4
CIS-4
SOCS4
STAI4
SOCS-4
SOCS-6
STATI4
HSPC060
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质包含一个SH2结构域和一个CIS同源结构域。因此,该蛋白质属于细胞因子诱导的STAT抑制剂(CIS),也称为细胞因子信号抑制子(SOCS)或STAT诱导的STAT抑制剂(SSI)蛋白质家族。CIS家族成员已知是细胞因子诱导的细胞因子信号的负调控因子。这个基因的表达可以在造血细胞中由GM-CSF和EPO诱导。在因子独立的慢性髓性白血病(CML)和红白血病(HEL)细胞系中,这个基因的高表达水平被发现在。[由RefSeq,2008年7月提供]
Related ID:
NCBI:9306
ENSEMBL:ENSG00000170677
HGNC:16833
UNIPROT:O14544
OMIM:605118
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
9306
10
2
41155 bp
59.53
13
--
3
4
SOCS6 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
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* This data comes from NCBI.
Gene Expression
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