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中文人类
TIFA - TRAF Interacting Protein With Forkhead Associated Domain
Alias:
T2BP
T6BP
TIFAA
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这个基因编码一种参与适应性和先天免疫的衔接蛋白。这种蛋白质包括一个特定的磷丝氨酸和苏氨酸残基结合的叉头相关(FHA)结构域。在细菌感染反应中，编码的宿主细胞蛋白质在FHA结构域与磷酸化的苏氨酸之间发生分子间相互作用，导致蛋白质寡聚化，并刺激NF-kappa B和其他下游信号传导途径。这种蛋白质在肝细胞癌中表达降低，可能抑制肝细胞癌的发展。这种蛋白质也可能在DNA损伤反应中发挥作用。[RefSeq，2018年6月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
TIFA Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
