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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
CCNE2 - Cyclin E2
Alias:
CYCE2
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质属于高度保守的细胞周期蛋白家族,其成员的特点是蛋白质在细胞周期中的含量具有明显的周期性变化。细胞周期蛋白作为CDK激酶的调节因子发挥作用。不同的细胞周期蛋白表现出不同的表达和降解模式,这有助于有丝分裂事件的时序协调。这个细胞周期蛋白与CDK2形成复合物并作为其调节亚基发挥作用。这个细胞周期蛋白已被证明特异性地与CIP/KIP家族CDK抑制剂相互作用,并在细胞周期G1/S过渡中发挥作用。这个基因在G1-S期的表达达到高峰,并且表现出与细胞周期蛋白E1不同的组织特异性模式。在肿瘤衍生细胞中,这个基因的表达水平显著增加。[由RefSeq,2008年7月提供]
Related ID:
NCBI:9134
ENSEMBL:ENSG00000175305
HGNC:1590
UNIPROT:O96020
OMIM:603775
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
9134
5
12
16470 bp
46.76
9
--
3
8
CCNE2 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
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Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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References Literature
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