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中文人类
USP2 - Ubiquitin Specific Peptidase 2
Alias:
USP9
UBP41
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这个基因编码去泛素酶家族的一员，属于肽酶C19超家族。编码的蛋白质是一种泛素特异性蛋白酶，是TNF-α（肿瘤坏死因子α）诱导的NF-kB（核因子kB）信号通路所必需的。这种蛋白质可以去除多泛素化靶蛋白，如脂肪酸合成酶、小鼠双分钟2（MDM2）、MDM4/MDMX和细胞周期蛋白D1。MDM2和MDM4是p53肿瘤抑制因子的负调控因子，而细胞周期蛋白D1是细胞周期G1/S过渡所必需的。已经识别出多种可变剪接转录变异体，它们编码不同的异构体。[由RefSeq，2011年8月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
USP2 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
