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中文人类
UBA3 - Ubiquitin Like Modifier Activating Enzyme 3
Alias:
NAE2
UBE1C
hUBA3
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泛素化是细胞内一种重要的蛋白质修饰机制，用于靶向异常或短寿命蛋白质进行降解。泛素化过程涉及至少三类酶：泛素活化酶（E1），泛素结合酶（E2）和泛素蛋白连接酶（E3）。这个基因编码一个E1泛素活化酶家族的成员。编码的酶与AppBp1（一种与淀粉样前体蛋白结合的蛋白质）结合，形成异源二聚体，然后激活NEDD8（一种调节细胞分裂、信号传导和胚胎发生的泛素样蛋白）。已在这个基因中发现多个可变剪接的转录变异体，编码不同的异构体。[RefSeq，2008年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
UBA3 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
