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中文人类
UBE3B - Ubiquitin Protein Ligase E3B
Alias:
KOS
BPIDS
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泛素化是细胞内一种重要的蛋白质修饰机制，用于靶向异常或短寿命蛋白质进行降解。泛素化涉及至少三类酶：E1泛素活化酶、E2泛素结合酶和E3泛素蛋白连接酶。这个基因编码一个E3泛素结合酶家族的成员，从E2泛素结合酶接受泛素并将其转移到目标底物。这个蛋白的较长异型的C端有一个HECT（与E6-AP C端同源）结构域，这是泛素转移的催化位点，并与E2结合酶形成复合物。这个蛋白的较短异型缺乏C端的HECT结构域，因此不太可能结合E2酶。这个基因的不同异型已经通过可变剪接转录物被识别。[RefSeq，2012年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
UBE3B Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
