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中文人类
MVB12B - Multivesicular Body Subunit 12B
Alias:
C9orf28
FAM125B
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这个基因编码的蛋白质是ESCRT-I复合物的组成部分，这是一个异四聚体，负责将泛素化货物的蛋白质从质膜分拣到内体囊泡中。ESCRT-I复合物在HIV出芽和内体蛋白质分拣中起着至关重要的作用。这个和相关蛋白质（MVB12A）的耗竭和过表达会抑制HIV-1感染性并诱导异常的病毒组装缺陷，表明MVB12亚基在调节ESCRT介导的病毒出芽中发挥作用。已发现这个基因有不同的剪接转录变异体，它们编码不同的异构体。[RefSeq，2011年8月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
MVB12B Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
