Picalm - phosphatidylinositol binding clathrin assembly protein

Enables several functions, including SH3 domain binding activity; identical protein binding activity; and phosphatidylinositol binding activity. Involved in several processes, including generation of neurons; positive regulation of dendrite extension; and positive regulation of transport. Located in several cellular components, including cytoplasmic vesicle; postsynaptic density; and synaptic membrane. Is intrinsic component of membrane. Is active in Schaffer collateral - CA1 synapse; parallel fiber to Purkinje cell synapse; and postsynapse. Is extrinsic component of presynaptic endocytic zone membrane. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human PICALM (phosphatidylinositol binding clathrin assembly protein). [provided by Alliance of Genome Resources, Apr 2022]