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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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CCND3 - Cyclin D3
Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质属于高度保守的细胞周期蛋白家族,其成员的特征是通过细胞周期的蛋白质丰度呈现显著周期性变化。细胞周期蛋白作为CDK激酶的调节因子发挥作用。不同的细胞周期蛋白表现出不同的表达和降解模式,这有助于有丝分裂事件的时序协调。这个细胞周期蛋白与CDK4或CDK6形成复合物并作为其调节亚基发挥作用,CDK4/6的活性是细胞周期G1/S过渡所必需的。这个蛋白质已被证明与肿瘤抑制蛋白Rb的磷酸化相互作用并涉及其中。与这个细胞周期蛋白相关的CDK4活性据报道在UV辐射后通过G2期进入有丝分裂的细胞周期进展是必需的。已经发现这个基因的几种转录变异体编码不同的异构体。[由RefSeq,2008年10月提供]
Related ID:
NCBI:896
ENSEMBL:ENSG00000112576
HGNC:1585
UNIPROT:P30281
OMIM:123834
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
896
17
5
115103 bp
32.52
11
--
9
19
CCND3 Genetics information (-)
GRCh38
Chr : -
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
No data available
Transcripts & Proteins
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#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
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Interactions
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Acting
Regulation
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Type
Name
MGI
Strain of Origin
Publications
No data available
Related Drugs
Name
CAS Number
Status
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Link
No data available
References Literature
Title
PMID
Journal
Year
IF
No Data Found!
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