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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
CCNA1 - Cyclin A1
Alias:
CT146
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
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References Literature
这个基因编码的蛋白质属于高度保守的细胞周期蛋白家族,其成员的特征是通过细胞周期的蛋白质丰度呈现明显的周期性变化。细胞周期蛋白作为CDK激酶的调节因子发挥作用。不同的细胞周期蛋白表现出不同的表达和降解模式,这有助于有丝分裂事件的时序协调。这个基因编码的细胞周期蛋白在睾丸和大脑中表达,以及在几个白血病细胞系中表达,被认为主要是在控制生殖系减数分裂细胞周期的过程中发挥作用。这个细胞周期蛋白与CDK2和CDC2激酶结合,产生两种不同的激酶活性,一种出现在S期,另一种出现在G2期,从而在细胞周期中调节不同的功能。这个细胞周期蛋白被发现与重要的细胞周期调节因子结合,如Rb家族蛋白、转录因子E2F-1和p21家族蛋白。已发现这个基因有多个编码不同异型的转录变异体。[由RefSeq,2008年7月提供]
Related ID:
NCBI:8900
ENSEMBL:ENSG00000133101
HGNC:1577
UNIPROT:P78396
OMIM:604036
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
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Reference
8900
7
9
11354 bp
52.36
20
--
3
8
CCNA1 Genetics information (+)
GRCh38
Sequence Homology
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* This data comes from NCBI.
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