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中文人类
MCM3AP - Minichromosome Maintenance Complex Component 3 Associated Protein
Alias:
GANP
SAC3
MAP80
PNRIID
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微染色体维持蛋白3（MCM3）是启动DNA复制所必需的MCM蛋白之一。这个基因编码的蛋白质是一种与MCM3结合的蛋白质。据报道，它具有依赖于磷酸化的DNA-引物酶活性，这种活性在抗原免疫诱导的生发中心中被上调。该蛋白质被证明是一种乙酰转移酶，可以乙酰化MCM3，并在DNA复制中发挥作用。MCM3的核定位信号的突变影响这个蛋白质与MCM3的结合，这表明这个蛋白质也可能促进MCM3的核定位。这个基因在大脑或神经组织中表达。已经在一个患有轻度智力障碍的患者中识别出一种等位基因变异，该变异编码915位的氨基酸赖氨酸，而不是保守的谷氨酸。[RefSeq，2014年1月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
MCM3AP Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
