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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
CDC16 - Cell Division Cycle 16
Alias:
APC6
CUT9
ANAPC6
CDC16Hs
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
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References Literature
这个基因编码的蛋白质作为泛素连接酶发挥作用,是多个蛋白质的APC复合物的组成部分。APC复合物是一个细胞周期蛋白降解系统,通过将细胞周期蛋白靶向26S蛋白酶体进行降解,从而控制有丝分裂的退出。APC复合物的每个组成蛋白质在真核生物中高度保守。这种蛋白质和其他APC复合物蛋白质含有四肽重复序列(TPR)结构域,该结构域通常涉及蛋白质-蛋白质相互作用和多蛋白质复合物的组装。已经鉴定出多种可变剪接转录变异体,它们编码不同的蛋白质。[RefSeq,2016年1月提供]
Related ID:
NCBI:8881
ENSEMBL:ENSG00000130177
HGNC:1720
UNIPROT:Q13042
OMIM:603461
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
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Reference
8881
18
18
37827 bp
71.66
29
--
3
19
CDC16 Genetics information (+)
GRCh38
Sequence Homology
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* This data comes from NCBI.
Gene Expression
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