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中文人类
SPHK1 - Sphingosine Kinase 1
Alias:
SPHK
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这个基因编码的蛋白质催化鞘氨醇磷酸化，形成具有细胞内和细胞外功能的脂质介质-1-磷酸鞘氨醇(S1P)。在细胞内，S1P调节增殖和生存，而在细胞外，它是细胞表面G蛋白偶联受体的配体。这个蛋白质及其产物S1P在TNF-alpha信号传导和NF-kappa-B激活途径中起着关键作用，这些途径在炎症、抗凋亡和免疫过程中起着重要作用。这个蛋白质的磷酸化改变其催化活性并促进其向质膜转移。可变剪接产生多个编码不同异构体的转录变异体。[由RefSeq，2017年9月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
SPHK1 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
