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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
IL18R1 - Interleukin 18 Receptor 1
Alias:
CD218a
IL18RA
IL1RRP
CDw218a
IL-1Rrp
IL-18Ralpha
IL18Ralpha2
IL-18R-alpha
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是一种属于白细胞介素1受体家族的细胞因子受体。这个受体特异地结合白细胞介素18(IL18),并且对于IL18介导的信号传导是必不可少的。据报道,IFN-alpha和IL12能够诱导NK细胞和T细胞中这个受体的表达。这个基因与白细胞介素1受体家族的四个其他成员(包括IL1R2、IL1R1、ILRL2(IL-1Rrp2)和IL1RL1(T1/ST2))一起,在染色体2q上形成一个基因簇。已经发现这个基因的不同剪接转录变异体编码不同的异构体。[由RefSeq,2013年9月提供]
Related ID:
NCBI:8809
ENSEMBL:ENSG00000115604
HGNC:5988
UNIPROT:Q13478
OMIM:604494
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
8809
15
11
42981 bp
62.30
16
--
6
11
IL18R1 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
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Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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