人类

TNFSF9 - TNF Superfamily Member 9

Alias:
CD137L
TNLG5A
4-1BB-L
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是一种属于肿瘤坏死因子(TNF)配体家族的细胞因子。这种跨膜细胞因子作为TNFRSF9/4-1BB的配体,是一种在T淋巴细胞中的共刺激受体分子。这个细胞因子及其受体参与抗原提呈过程和细胞毒性T细胞的生成。受体TNFRSF9/4-1BB在静息的T淋巴细胞中缺失,但在抗原刺激后迅速表达。这个基因编码的配体TNFSF9/4-1BBL已显示能重新激活无反应的T淋巴细胞,并促进T淋巴细胞的增殖。这个细胞因子也被证明对CD8+ T细胞的优化CD8反应是必需的。这个细胞因子在癌细胞的细胞系中表达,被认为涉及T细胞与肿瘤细胞的相互作用。[RefSeq,2008年10月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
1
3
4899 bp
26.62
9
--
4
5

TNFSF9 Genetics information (+)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
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#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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