人类

TNFRSF25 - TNF Receptor Superfamily Member 25

Alias:
DR3
TR3
DDR3
LARD
APO-3
TRAMP
WSL-1
GEF720
WSL-LR
PLEKHG5
TNFRSF12
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是肿瘤坏死因子受体超家族的一员。这个受体在富含淋巴细胞的组织中表达偏好,可能在调节淋巴细胞稳态中发挥作用。这个受体已被证明能刺激NF-kappa B活性并调节细胞凋亡。这个受体的信号传导由各种含死亡结构域的适配蛋白介导。在小鼠中进行的敲除研究表明,这个基因在胸腺中去除自身反应性T细胞的作用。这个基因有多个可变剪接转录变体,编码不同的等位基因,其中大多数可能是分泌分子。这个基因在B和T细胞中的可变剪接在T细胞激活后遇到程序性改变,主要产生全长膜结合等位基因,被认为参与控制由T细胞激活引起的淋巴细胞增殖。[由RefSeq提供,2008年7月]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
6
10
5388 bp
45.38
23
--
7
12

TNFRSF25 Genetics information (-)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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