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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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TNFRSF25 - TNF Receptor Superfamily Member 25
Alias:
DR3
TR3
DDR3
LARD
APO-3
TRAMP
WSL-1
GEF720
WSL-LR
PLEKHG5
TNFRSF12
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是肿瘤坏死因子受体超家族的一员。这个受体在富含淋巴细胞的组织中表达偏好,可能在调节淋巴细胞稳态中发挥作用。这个受体已被证明能刺激NF-kappa B活性并调节细胞凋亡。这个受体的信号传导由各种含死亡结构域的适配蛋白介导。在小鼠中进行的敲除研究表明,这个基因在胸腺中去除自身反应性T细胞的作用。这个基因有多个可变剪接转录变体,编码不同的等位基因,其中大多数可能是分泌分子。这个基因在B和T细胞中的可变剪接在T细胞激活后遇到程序性改变,主要产生全长膜结合等位基因,被认为参与控制由T细胞激活引起的淋巴细胞增殖。[由RefSeq提供,2008年7月]
Related ID:
NCBI:8718
ENSEMBL:ENSG00000215788
HGNC:11910
UNIPROT:Q93038
OMIM:603366
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
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Reference
8718
6
10
5388 bp
45.38
23
--
7
12
TNFRSF25 Genetics information (-)
GRCh38
Sequence Homology
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* This data comes from NCBI.
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