人类

TNK1 - Tyrosine Kinase Non Receptor 1

Alias:
KOS1
Favorite
Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质属于酪氨酸蛋白激酶家族。酪氨酸蛋白激酶是细胞内信号传导途径的重要调节剂,调节细胞增殖、生存和发育。这个基因在胎儿组织中高度表达,而在少数成人组织中的表达水平较低,因此可能在胎儿发育过程中广泛使用的信号通路中发挥作用,而在成人组织中更有选择性地发挥作用。它在大鼠-Raf1-MAPK途径中扮演负调控角色,并且已经证明敲除小鼠会自发产生肿瘤,表明它是一个肿瘤抑制基因。已经发现这个基因有不同的剪接转录变异体,编码不同的异构体。[RefSeq, 2011年10月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
6
13
9696 bp
72.47
32
--
5
13

TNK1 Genetics information (+)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
Wechat
Mutation Direct
Sequence
Comparison
Al agent
Tutorials
Back to top