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中文人类
CBLB - Cbl Proto-oncogene B
Alias:
Cbl-b
RNF56
Nbla00127
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这个基因编码一个E3泛素-蛋白连接酶，通过将泛素从E2泛素结合酶转移到底物，促进蛋白酶体介导的蛋白质降解。编码的蛋白质参与通过限制T细胞受体、B细胞受体和高亲和力免疫球蛋白ε受体的激活，来调节免疫反应。研究表明，这个基因参与抗真菌宿主防御，其抑制导致真菌杀伤增加。操纵这个基因可能在实施针对多种疾病的免疫疗法中有益，包括癌症、自身免疫性疾病、过敏和感染。[RefSeq, 2017年9月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
CBLB Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
