人类

TP63 - Tumor Protein P63

Alias:
AIS
KET
LMS
NBP
RHS
p40
p51
p63
EEC3
OFC8
p73H
p73L
SHFM4
TP53L
TP73L
p53CP
TP53CP
B(p51A)
B(p51B)
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码p53家族转录因子的一员。p53家族蛋白的功能结构域包括N端激活结构域,中央DNA结合结构域和寡聚结构域。这个基因的可变剪接和替代启动子的使用导致编码不同功能特性的不同剪接变异体的多种转录本。这些异构体在皮肤发育和维护,成年干/祖细胞调节,心脏发育和过早衰老过程中发挥作用。已经发现某些异构体通过消除遭受DNA损伤的卵母细胞或睾丸生殖细胞来保护种系。这个基因的突变与外胚层发育不良和裂唇/腭综合征3(EEC3);分裂手/足畸形4(SHFM4);倒睫-外胚层缺陷-裂唇/腭;成人综合征(肢端-皮肤-指甲-泪腺-牙齿);肢-乳腺综合征;Rap-霍奇金综合征(RHS);和口面部裂8相关。[RefSeq提供,2016年8月]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
13
14
300531 bp
76.78
577
16
28
40

TP63 Genetics information (+)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Mutation Direct
Sequence
Comparison
Al agent
Tutorials
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