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中文人类
MADD - MAP Kinase Activating Death Domain
Alias:
DENN
IG20
DEEAH
RabGEF
NEDDISH
RAB3GEP
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肿瘤坏死因子α（TNF-α）是一种信号分子，与靶向细胞中的两种受体之一相互作用，导致细胞凋亡。细胞内的细胞质衔接蛋白在这些细胞内传递凋亡信号。这个基因编码的蛋白质是一种含有死亡结构域的衔接蛋白，与TNF-α受体1的死亡结构域相互作用，激活有丝分裂原激活的蛋白激酶（MAPK）并传播凋亡信号。它是膜结合的，并且在肿瘤细胞中的表达水平高于正常细胞。已经描述了这个基因的几个转录变异体，编码不同的异构体。[由RefSeq，2008年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
MADD Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
