Log In|Sign Up
中文人类
ITGA8 - Integrin Subunit Alpha 8
Favorite
整合素是异源二聚跨膜受体蛋白，可调节许多细胞过程，包括细胞粘附、细胞骨架重排和细胞信号通路激活。整合素由α和β亚基组成。该基因编码异源二聚整合素α8β1蛋白的α8亚基。编码的蛋白质是含有多个FG-GAP重复序列的单通过类型1膜蛋白。该重复序列预测会折叠成β螺旋结构。该基因调节间充质细胞招募到上皮结构中，调节细胞间相互作用，并调节感觉和运动神经元的轴突生长。因此，整合素α8β1蛋白在伤口愈合和器官发生中起着重要作用。与这种基因相关的突变已与肾发育不良/缺如1（RHDA1）和几种慢性肾病动物模型相关。交替剪接导致编码不同异构体的多种转录变异体。[由RefSeq，2014年4月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
ITGA8 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
