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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
NR0B2 - Nuclear Receptor Subfamily 0 Group B Member 2
Alias:
SHP
SHP1
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是一个不寻常的孤儿受体,它包含一个可能的配体结合域,但缺乏一个常规的DNA结合域。基因产物是核激素受体家族的一员,这是一个由小亲脂性激素调节的一组转录因子,其中一部分没有已知的配体,被称为孤儿核激素受体。该蛋白质已被证明与视黄醇和甲状腺激素受体相互作用,抑制其配体依赖性的转录激活。此外,与雌激素受体的相互作用已被证实,导致功能抑制。研究表明,该蛋白质通过两个独立步骤抑制核激素受体介导的转录激活:与共激活剂的竞争和其转录抑制功能的直接影响。[由RefSeq提供,2008年7月]
Related ID:
NCBI:8431
ENSEMBL:ENSG00000131910
HGNC:7961
UNIPROT:Q15466
OMIM:604630
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
8431
2
2
2487 bp
28.06
51
1
11
10
NR0B2 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
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No data available
Transcripts & Proteins
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Transcript
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* This data comes from NCBI.
Gene Expression
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