人类

NR0B2 - Nuclear Receptor Subfamily 0 Group B Member 2

Alias:
SHP
SHP1
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是一个不寻常的孤儿受体,它包含一个可能的配体结合域,但缺乏一个常规的DNA结合域。基因产物是核激素受体家族的一员,这是一个由小亲脂性激素调节的一组转录因子,其中一部分没有已知的配体,被称为孤儿核激素受体。该蛋白质已被证明与视黄醇和甲状腺激素受体相互作用,抑制其配体依赖性的转录激活。此外,与雌激素受体的相互作用已被证实,导致功能抑制。研究表明,该蛋白质通过两个独立步骤抑制核激素受体介导的转录激活:与共激活剂的竞争和其转录抑制功能的直接影响。[由RefSeq提供,2008年7月]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
2
2
2487 bp
28.06
51
1
11
10

NR0B2 Genetics information (-)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Comparison
Al agent
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