人类

BCAR3 - BCAR3 Adaptor Protein, NSP Family Member

Alias:
MIG7
NSP2
AND-34
SH2D3B
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
乳腺癌最初依赖于雌激素的生长和进展,并可以通过如他莫昔芬等抗雌激素药物抑制。然而,乳腺癌会发展成为抗雌激素抵抗。在寻找参与雌激素抵抗发展的基因时,发现了乳腺癌抗雌激素抵抗基因3。该基因编码细胞内信号转导的一个组成部分,导致人乳腺癌细胞的雌激素独立增殖。该蛋白质包含一个可能的src同源2(SH2)域,这是细胞酪氨酸激酶信号分子的标志,部分与细胞分裂周期蛋白CDC48同源。对于这个基因,已经发现了多种转录变体,编码不同的等位基因。[由RefSeq提供,2012年5月]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
33
12
286411 bp
92.57
51
--
5
21

BCAR3 Genetics information (-)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Mutation Direct
Sequence
Comparison
Al agent
Tutorials
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