Kremen1 - kringle containing transmembrane protein 1

Involved in several processes, including negative regulation of axon regeneration; negative regulation of canonical Wnt signaling pathway; and negative regulation of ossification. Located in neuronal cell body. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb ectoderm; and sensory organ. Human ortholog(s) of this gene implicated in ectodermal dysplasia 13. Orthologous to human KREMEN1 (kringle containing transmembrane protein 1). [provided by Alliance of Genome Resources, Apr 2022]