Tfam - transcription factor A, mitochondrial

Enables heat shock protein binding activity and transcription coactivator binding activity. Predicted to be involved in positive regulation of transcription, DNA-templated and transcription initiation from mitochondrial promoter. Predicted to act upstream of or within mitochondrial respiratory chain complex assembly. Located in mitochondrion. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; amyotrophic lateral sclerosis; and mitochondrial DNA depletion syndrome 15. Orthologous to human TFAM (transcription factor A, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]