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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
FZD6 - Frizzled Class Receptor 6
Alias:
FZ6
FZ-6
HFZ6
NDNC1
NDNC10
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因属于“frizzled”基因家族的一员,它编码7个跨膜结构域蛋白,作为Wnt信号蛋白的受体。这个家族成员编码的蛋白质包含一个信号肽,N端细胞外区域的一个富含半胱氨酸的结构域,以及七个跨膜结构域,但与其他家族成员不同,这个蛋白质不包含C端的PDZ结构域结合基序。这个蛋白质作为正则Wnt/beta-catenin信号级联的负调控因子,从而抑制触发癌基因转化、细胞增殖和抑制凋亡的过程。可变剪接产生多个转录变异体,其中一些不编码具有预测信号肽的蛋白质。[RefSeq,2011年8月提供]
Related ID:
NCBI:8323
ENSEMBL:ENSG00000164930
HGNC:4044
UNIPROT:O60353
OMIM:603409
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
8323
4
7
34373 bp
79.29
33
2
9
10
FZD6 Genetics information (+)
GRCh38
Sequence Homology
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* This data comes from NCBI.
Gene Expression
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