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中文人类
CDC45 - Cell Division Cycle 45
Alias:
CDC45L
MGORS7
CDC45L2
PORC-PI-1
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这个基因编码的蛋白质与酿酒酵母Cdc45蛋白具有强烈的相似性，Cdc45蛋白是DNA复制起始所必需的基本蛋白质。Cdc45是高度保守的多蛋白复合体的一部分，该复合体包括Cdc6/Cdc18、迷你染色体维持蛋白（MCMs）和DNA聚合酶，这些在真核生物DNA复制的早期步骤中起着重要作用。该蛋白质已被证明与MCM7和DNA聚合酶α相互作用。青蛙中类似基因的研究表明，该蛋白质在将DNA聚合酶α加载到染色质上起着关键作用。交替剪接导致多个转录变异体。[RefSeq，2013年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
CDC45 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
