Msh2 - mutS homolog 2

Predicted to enable several functions, including ATP hydrolysis activity; DNA binding activity; and protein C-terminus binding activity. Predicted to contribute to several functions, including DNA binding activity; MutLalpha complex binding activity; and adenyl ribonucleotide binding activity. Involved in several processes, including response to amino acid; response to xenobiotic stimulus; and spermatogenesis. Located in nucleus. Biomarker of colitis and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome (multiple); gastrointestinal system cancer (multiple); lung cancer (multiple); mismatch repair cancer syndrome; and transitional cell carcinoma. Orthologous to human MSH2 (mutS homolog 2). [provided by Alliance of Genome Resources, Apr 2022]