Adar - adenosine deaminase, RNA-specific

Predicted to enable double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and tRNA-specific adenosine deaminase activity. Predicted to be involved in several processes, including RNA metabolic process; negative regulation of protein kinase activity by regulation of protein phosphorylation; and nucleocytoplasmic transport. Predicted to act upstream of or within several processes, including gene silencing by miRNA; hematopoietic stem cell homeostasis; and immune system development. Located in nuclear speck and nucleolus. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Human papillomavirus infectious disease; dyschromatosis symmetrica hereditaria; and liver cirrhosis. Orthologous to human ADAR (adenosine deaminase RNA specific). [provided by Alliance of Genome Resources, Apr 2022]