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中文人类
CDK2AP1 - Cyclin Dependent Kinase 2 Associated Protein 1
Alias:
DOC1
ST19
DORC1
doc-1
p12DOC-1
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这个基因编码的蛋白质是一种与细胞周期蛋白依赖的激酶2（CDK2）相关的蛋白质，被认为通过隔离单体CDK2并使其成为蛋白水解的靶点，从而负调控CDK2的活性。该蛋白质还发现与DNA聚合酶α/primase相互作用，并介导对大型p180亚基的磷酸化，这表明在细胞周期的S期在DNA复制中具有调节作用。该蛋白质还形成核小体重塑和组蛋白脱乙酰化（NURD）复合体的核心亚单位，该复合体表观地调节胚胎干细胞的分化。因此，这个基因在细胞周期和表观遗传调控中发挥作用。可变剪接导致多个转录变异体，编码不同的异构体。[由RefSeq，2012年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
CDK2AP1 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
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Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
