人类

PTP4A2 - Protein Tyrosine Phosphatase 4A2

Alias:
HH13
OV-1
PRL2
HH7-2
PRL-2
PTP4A
HU-PP-1
PTPCAAX2
ptp-IV1a
ptp-IV1b
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质属于蛋白酪氨酸磷酸酶(PTP)家族的一个小类。PTP是细胞信号分子,在各种细胞过程中发挥调节作用。这个类别的PTP包含一个蛋白酪氨酸磷酸酶催化域和一个特征性的C末端预酰化模序。这个PTP已经显示出主要通过其C末端预酰化与血浆和内体膜结合。这个PTP被发现与Rab geranylgeranyltransferase II (beta GGT II)的β亚基相互作用,因此可能作为GGT II活性的调节器。这个基因在哺乳动物细胞中的过表达赋予了转化表型,这表明它在肿瘤发生中的作用。已经描述了该基因的可变剪接转录变体。在11、12和17号染色体上存在相关的假基因。[由RefSeq提供,2010年8月]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
6
6
31948 bp
19.13
3
--
7
15

PTP4A2 Genetics information (-)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Mutation Direct
Sequence
Comparison
Al agent
Tutorials
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