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中文人类
MUS81 - MUS81 Structure-specific Endonuclease Subunit
Alias:
SLX3
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这个基因编码一种属于XPF/MUS81内切核酸酶家族的特异性结构内切核酸酶，在DNA修复、链间交叉连接、复制叉塌陷和DNA双链断裂后，在重组中间体的解决中扮演关键角色。编码的蛋白质与两种密切相关的基本减数性内切核酸酶蛋白（EME1或EME2）之一结合，形成处理DNA二级结构的复合物。它包含一个N-端DEAH螺旋酶结构域、一个切除修复交叉互补组4（ERCC4）内切核酸酶结构域和两个串联的C-端螺旋-发卡-螺旋结构域。与其正链同源基因敲除的小鼠具有显著的减数性缺陷，包括不能修复一部分DNA双链断裂。[RefSeq，2017年6月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
MUS81 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
