Atf4 - activating transcription factor 4

Enables DNA-binding transcription factor binding activity; general transcription initiation factor binding activity; and protein C-terminus binding activity. Involved in several processes, including cellular response to oxygen-glucose deprivation; positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress; and response to manganese-induced endoplasmic reticulum stress. Located in cytoplasm; dendrite membrane; and nucleus. Biomarker of borna disease and pulmonary venoocclusive disease. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human ATF4 (activating transcription factor 4). [provided by Alliance of Genome Resources, Apr 2022]