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中文人类
VKORC1 - Vitamin K Epoxide Reductase Complex Subunit 1
Alias:
VKOR
MST134
MST576
VKCFD2
EDTP308
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这个基因编码维生素K环氧化物还原酶复合物的催化亚基，负责将活性维生素K 2,3-环氧化物还原为内质网膜中的活性维生素K。维生素K是维生素K依赖性γ-羧化酶在凝血酶中谷氨酸残基羧基化的必需辅因子。这个基因的等位基因变异与维生素K依赖的凝血因子2合并缺陷以及对华法林的抵抗或敏感性增加，华法林是维生素K环氧化物还原酶的抑制剂。这个基因的假基因位于染色体1和X上。可变剪接导致多个转录变异体。[RefSeq，2015年8月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
VKORC1 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
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Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
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Tile View
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Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
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MGI
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References Literature
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