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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
ZYX - Zyxin
Alias:
ESP-2
HED-2
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
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聚焦粘附是使细胞能够粘附到细胞外基质上的肌动蛋白丰富的结构,并且涉及信号转导的蛋白质复合体在此处组装。Zyxin 是一种锌结合磷酸蛋白,它集中在聚焦粘附处和肌动蛋白细胞骨架上。Zyxin 在其 C-端半部分具有一个 N-端富脯氨酸结构域和三个 LIM 结构域。富脯氨酸结构域可能与涉及信号转导途径的蛋白质的 SH3 结构域相互作用,而 LIM 结构域可能涉及蛋白质-蛋白质结合。Zyxin 可以作为信号转导途径中的信使,该途径调节粘附刺激下的基因表达变化,并可能调节肌动蛋白束的细胞骨架组织。可变剪接产生编码相同异构体的多种转录变异体。[由 RefSeq,2008 年 7 月提供]
Related ID:
NCBI:7791
ENSEMBL:ENSG00000159840
HGNC:13200
UNIPROT:Q15942
OMIM:602002
Basic Information
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7791
5
10
9767 bp
61.28
34
--
4
29
ZYX Genetics information (+)
GRCh38
Sequence Homology
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* This data comes from NCBI.
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