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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
PCGF2 - Polycomb Group Ring Finger 2
Alias:
TPFS
MEL-18
RNF110
ZNF144
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质包含一个RING指结构并类似于polycomb组(PcG)的基因产物。PcG基因产物通过蛋白质-蛋白质相互作用形成复合物,并维持参与胚胎发生、细胞周期和肿瘤发生的基因的转录抑制。这个蛋白质被证明是转录的负调控因子,并具有肿瘤抑制活性。这个基因在各种肿瘤细胞中表达,但在正常组织的神经器官中表达有限。在小鼠中的敲除研究表明,这个蛋白质可能负调控不同细胞因子、趋化因子和趋化因子受体的表达,从而在淋巴细胞分化和迁移以及免疫应答中发挥着重要作用。[由RefSeq,2008年7月提供]
Related ID:
NCBI:7703
ENSEMBL:ENSG00000277258
HGNC:12929
UNIPROT:P35227
OMIM:600346
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
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Reference
7703
6
11
15895 bp
37.79
155
1
7
10
PCGF2 Genetics information (-)
GRCh38
Sequence Homology
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* This data comes from NCBI.
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